Glucosamine Sulfate

The Universal Builder

Glucosamine Sulphate is an amino sugar that contains the sulphur needed for cartilage synthesis. It is a natural component of all tissues including cartilage and joints. Usually, it comes from animal sources including shellfish/ crustaceans. Rarely does it come from vegan sources.

Though it is always thought of as a joint health supplement, the amino sugar has been documented to show benefits for many conditions including inflammatory/ autoimmune conditions, joint degenerative conditions and age-related/ inflammatory skin conditions.

Key Health Benefits

Osteoarthritis pain

Joint lubrication

Stops cartilage loss

Soft tissues repair

Anti-inflammatory For those with high activity Joint regeneration

Component of cartilage matrix

Need to rebuild and repair 

Extensively studied 

Used by veterinarians for feline cystitis

Part of Ayurvedic medicine High safety profile

Does not increase blood sugar significantly

Good for skin health

Increases the production of hyaluronic acid Anti-aging

Modulation of gut microbiota

Preserves mitochondria

The Ubiquatous Building Block

Many see glucosamine as a join-health support agent that is meant to cover for the wear and tear through joints and while that point of view is not exactly incorrect, there is much more to the story. Glucosamine is a ubiquitous building block that can be good for skin health, bone health and joint health. It is demonstrated to have a significant anti-inflammatory function and is great at maintaining tissue lubrication. Whether it is the stressed-out joints or the skin that is not responding to external moisturization, glucosamine is the ingredient to maintain internal moisturization and preserve tissues in a healthy enough condition for them to function optimally.

The Different Types of Glucosamine

Glucosamine supplements are very similar but maybe of slightly different functionality. Glucosamine comes in glucosamine sulphate, N-acetyl glucosamine and glucosamine hydrochloride preparation.

Evidence shows that glucosamine chloride is the type of glucosamine with the most research backing up its use as an osteoarthritis agent. It is demonstrated to slow down the degeneration of joints and may play a role in decreasing inflammation.

On the other hand, glucosamine hydrochloride appears to function more for pain management.

Finally, N-acetyl glucosamine plays a role in osteoarthritis, gut maintenance and probiotic balance.


Glucosamine usually comes from shellfish. Rarely, come companies obtain glucosamine from corn-starch to offer a vegan option.